Cell Biology

Count on our advanced functionalities

Cell biology comprises numerous disciplines such as organelle biology, cell division, cytoskeleton, genome biology, differentiation, cellular dynamics, and transport.

Research in modern cell biology is frequently based on living and fixed cultured cells using a variety of research approaches and tools, where light microscopy is one of the most important for this discipline.

Because the size of organelles and other intracellular structures is often below the resolution limit of conventional light microscopy, super-resolution techniques such as STED and MINFLUX are now frequently used for research in cell biology.

Abberior offers several unique microscope features which facilitate imaging of fixed and living cell samples over extended time periods at the highest possible resolution:

• MINFLUX imaging mode for resolutions down to 2 nm

• MINFLUX single particle tracking with up to 10 kHz, i.e., 1 data point every 100 µs

• Adaptive Illumination for super-resolution STED imaging at minimal light dosages

• Lifetime imaging and advanced time-gating

• Pulsed high-power STED lasers for best resolutions with 2D and 3D super-resolution nanoscopy

• Detectors with superior detection efficiency (up to 65%)

Year	Journal	Author	Title
2006	Nature	Katrin I Willig et al.​	STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2009	Nature Methods	Stefan W Hell et al.	Microscopy and its focal switch
2011	Biophysical Journal	Jan Tonnesen et al.	Two-color STED microscopy of living synapses using a single laser-beam pair
​2012	Journal of Molecular and Cellular Cardiology	S. Mitchell-Jordan et al.	Features of endogenous cardiomyocyte chromatin revealed by super-resolution STED microscopy
2012	ChemPhysChem	Tobias Muller et al.	​STED Microscopy and its Applications/ New Insights into Cellular Processes on the Nanoscale
2015	Methods Mol Biol.	Natalia H. Revelo and Silvio O. Rizzoli	Application of STED microscopy to cell biology questions
2017	​International Journal of Molecular Sciences	Rafal Szatanek et al.	The Methods of Choice for Extracellular Vesicles (EVs) Characterization
2019	Journal of Physics D: Applied Physics.	Georgij Kostiuk et al.	Application of STED imaging for chromatin studies
2022	Nature	​Vladimir Riazanskil et al.	Real time imaging of single extracellular vesicle pH regulation in a microfluidic cross-flow filtration platform